Publication Laka-library:
Enriched but not depleted uranium affects central nervous system in long-term exposed rat

AuthorHoupert, Lestaevel, Bussy…
6-05-0-00-26.pdf
DateApril 2005
Classification 6.05.0.00/26 (DEPLETED URANIUM - GENERAL (F.I. HEALTH CONSEQUENCES))
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                                         NeuroToxicology xxx (2005) xxx–xxx




    Enriched But Not Depleted Uranium Affects
       Central Nervous System In Long-Term
                   Exposed Rat
              Pascale Houpert 1, Philippe Lestaevel 1,*,1, Cyrill Bussy 1, Franc¸ois Paquet 1,
                                          Patrick Gourmelon 2
          1
            Institut de Radioprotection et de Suˆrete´ Nucle´aire, Direction de la Radioprotection de l’Homme – Service de
          Radiobiologie et d’E´pide´miologie, Laboratoire de Radiotoxicologie Expe´rimentale, BP 166-26702 Pierrelatte,
          France
          2
            Institut de Radioprotection et de Suˆrete´ Nucle´aire, Direction de la Radioprotection de l’Homme,
          BP17-92262 Fontenay-aux-Roses, France
                                               Received 8 February 2005; accepted 22 April 2005




                                                                  Abstract

             Uranium is well known to induce chemical toxicity in kidneys, but several other target organs, such as central nervous
          system, could be also affected. Thus in the present study, the effects on sleep–wake cycle and behavior were studied after
          chronic oral exposure to enriched or depleted uranium. Rats exposed to 4% enriched uranium for 1.5 months through
          drinking water, accumulated twice as much uranium in some key areas such as the hippocampus, hypothalamus and
          adrenals than did control rats. This accumulation was correlated with an increase of about 38% of the amount of
          paradoxical sleep, a reduction of their spatial working memory capacities and an increase in their anxiety. Exposure to
          depleted uranium for 1.5 months did not induce these effects, suggesting that the radiological activity induces the primary
          events of these effects of uranium.
          # 2005 Elsevier Inc. All rights reserved.

          Keywords: Enriched