Publicatie Laka-bibliotheek:
Radiation-related genomic profile of papillary thyroid cancer after the Chernobyl accident

AuteurMorton, Karyadi, Stewart, Bogdanova, Dawson, Thomas
Datumapril 2021

Uit de publicatie:

The 1986 Chernobyl nuclear power plant accident increased papillary thyroid cancer (PTC) incidence in
surrounding regions, particularly for 131I-exposed children. We analyzed genomic, transcriptomic, and
epigenomic characteristics of 440 PTCs from Ukraine (359 with estimated childhood 131I exposure and 81
unexposed children born after 1986). PTCs displayed radiation dose-dependent enrichment of fusion
drivers, nearly all in the mitogen-activated protein kinase pathway, and increases in small deletions and
simple/balanced structural variants that were clonal and bore hallmarks of non-homologous end-joining
repair. Radiation-related genomic alterations were more pronounced for those younger at exposure.
Transcriptomic and epigenomic features were strongly associated with driver events but not radiation
dose. Our results point to DNA double-strand breaks as early carcinogenic events that subsequently
enable PTC growth following environmental radiation exposure.