Stichting Laka

Publicatie Laka-bibliotheek:
Diagnosis and treatment of patients with acute radiation syndromes. EUR 16535 EN (1996)

Auteur
Datum1996
Classificatie 2.34.8.11/17 (TSJERNOBYL - ONGELUK & OMGEVING - MEDISCH/MUTATIES)
Voorkant

Uit de publicatie:

II. BACKGROUND

The project aims primarily at a joint study on improvement of diagnosis and 
treatment of the effects of high dose accidental irradiation by means of:

• Evaluation of patients treated for acute radiation sickness after the Chernobyl 
accident;

• Studies on diagnosis and treatment of radiation damage to the blood cell 
production system, which belongs to the most radiation sensitive part of the body;

• Studies on diagnosis and treatment of radiation damage to the skin, which is 
frequently affected since acute localised irradiation and external contamination are 
the most frequent radiation accident events.

The Chernobyl accident offers a substantial number of high dose accident victims in 
the range of 1 to> 8 Gy exposures. Of 237 original patients, 138 were classified as 
patients which suffered from confirmed acute radiation sickness, of which 102 
survived and were/are in the process of rehabilitation. It is proposed to investigate 
these patients both retrospectively and prospectively, involving not only the blood 
cell production system and the skin, but also the gastrointestinal tract, the kidney, 
the liver, the central nervous system and endocrine functions.

For acute radiation damage to the blood cell production system, it is essential as 
quickly as possible in the initial phase after exposure to distinguish patients with 
sufficient residual hemopoietic recovery to survive with conventional supportive 
care and those which require intensive, sophisticated treatment in specialised 
centres, which may include treatment with hemopoietic growth factors, electively 
supported by (allogeneic) bone marrow transplantation.

The management of acute localised skin irradiation in patients after accidental 
exposure remains difficult to perform because the diagnosis of the extent of the 
irradiated tissues and therefore the prognosis are doubtful insofar as the early 
reaction is weak and varying. Needs for earlier and more accurate diagnostic 
methods do exist either for the acute inflammatory as well as for the secondary 
reaction and the following fibrosis and sclerosis processes. Strategies for treatment 
will be directed either towards the reduction of inflammation and oedema, or 
towards the improvement of vascular supply trying to avoid the reperfusion injury. 
Of particular concern is the prevention of fibrosis.

Deze publicatie is alleen op papier bij Laka beschikbaar, niet als pdf.
Publicaties zijn te leen of informeer of we een kopie kunnen maken. Soms, als we tijd hebben, lukt dat tegen kostprijs van de kopieën.