Publicatie Laka-bibliotheek:
Effects of short-term and long-term depleted uranium exposure on open-field behavior and brain lipid oxidation in rats
Auteur | W.Briner, J.Murray |
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6-05-0-00-24.pdf |
Datum | september 2004 |
Classificatie | 6.05.0.00/24 (VERARMD URANIUM - ALGEMEEN (oa. Gezondheidsonderzoek)) |
Voorkant | ![]() |
Uit de publicatie:
DTD 5 ARTICLE IN PRESS Neurotoxicology and Teratology xx (2004) xxx – xxx www.elsevier.com/locate/neutera Effects of short-term and long-term depleted uranium exposure on open-field behavior and brain lipid oxidation in rats Wayne Briner*, Jennifer Murray Department of Psychology, University of Nebraska at Kearney, Kearney, NE 68849, USA Received 9 March 2004; received in revised form 31 August 2004; accepted 1 September 2004 Abstract Male and female rats were exposed to depleted uranium acetate (DU) in drinking water at doses of 0, 75, or 150 mg/L for either 2 weeks or 6 months. After exposure, the animals were tested for behaviors in the open-field. After testing in the open-field, the brains were examined for levels of lipid oxidation using the thiobarbituric acid (TBA) assay. Behavioral differences (line crossing and rearing) were seen in male rats after 2 weeks exposure to DU in drinking water for the highest dose group. Increased brain lipid oxidation was seen for the highest dose group for both genders. Lipid oxidation levels correlated significantly with line crossing and rearing in the open-field. After 6 months exposure, behavioral differences for male rats in the open-field remained and expanded to include other behaviors (grooming, defecation, and urination). Female rats also demonstrated some behavioral changes after 6 months exposure. Lipid oxidation in the brain continued to be seen; however, these levels no longer correlated with open-field behaviors. These d