Publicatie Laka-bibliotheek:
Effects of short-term and long-term depleted uranium exposure on open-field behavior and brain lipid oxidation in rats

AuteurW.Briner, J.Murray
6-05-0-00-24.pdf
Datumseptember 2004
Classificatie 6.05.0.00/24 (VERARMD URANIUM - ALGEMEEN (oa. Gezondheidsonderzoek))
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                                                   ARTICLE IN PRESS


                                              Neurotoxicology and Teratology xx (2004) xxx – xxx
                                                                                                                      www.elsevier.com/locate/neutera




       Effects of short-term and long-term depleted uranium exposure on
              open-field behavior and brain lipid oxidation in rats
                                                   Wayne Briner*, Jennifer Murray
                                Department of Psychology, University of Nebraska at Kearney, Kearney, NE 68849, USA

                             Received 9 March 2004; received in revised form 31 August 2004; accepted 1 September 2004




Abstract

    Male and female rats were exposed to depleted uranium acetate (DU) in drinking water at doses of 0, 75, or 150 mg/L for either 2 weeks
or 6 months. After exposure, the animals were tested for behaviors in the open-field. After testing in the open-field, the brains were examined
for levels of lipid oxidation using the thiobarbituric acid (TBA) assay. Behavioral differences (line crossing and rearing) were seen in male
rats after 2 weeks exposure to DU in drinking water for the highest dose group. Increased brain lipid oxidation was seen for the highest dose
group for both genders. Lipid oxidation levels correlated significantly with line crossing and rearing in the open-field. After 6 months
exposure, behavioral differences for male rats in the open-field remained and expanded to include other behaviors (grooming, defecation, and
urination). Female rats also demonstrated some behavioral changes after 6 months exposure. Lipid oxidation in the brain continued to be
seen; however, these levels no longer correlated with open-field behaviors. These d