Publicatie Laka-bibliotheek:
Evaluation of the effect of implanted depleted uranium on male reproductive success, sperm concentration and sperm velocity
Auteur | Arfsten, Schaeffer, Johnson |
6-05-0-00-25.pdf | |
Datum | maart 2005 |
Classificatie | 6.05.0.00/25 (VERARMD URANIUM - ALGEMEEN (oa. Gezondheidsonderzoek)) |
Voorkant |
Uit de publicatie:
ARTICLE IN PRESS Environmental Research ] (]]]]) ]]]–]]] www.elsevier.com/locate/envres Evaluation of the effect of implanted depleted uranium on male reproductive success, sperm concentration, and sperm velocity$ Darryl P. Arfstena,Ã, David J. Schaefferb, Eric W. Johnsona, J. Robert Cunninghama, Kenneth R. Stilla, Erin R. Wilfonga a Naval Health Research Center Detachment, Environmental Health Effects Laboratory, Wright-Patterson AFB, OH 45433, USA b Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA Received 1 December 2004; received in revised form 21 March 2005; accepted 25 March 2005 Abstract Depleted uranium (DU) projectiles have been used in battle in Iraq and the Balkans and will continue to be a significant armor- penetrating munition for the US military. As demonstrated in the Persian Gulf War, battle injury from DU projectiles and shrapnel is a possibility, and removal of embedded DU fragments from the body is not always practical because of their location in the body or their small size. Previous studies in rodents have demonstrated that implanted DU mobilizes and translocates to the gonads, and natural uranium may be toxic to spermatazoa and the male reproductive tract. In this study, the effects of implanted DU pellets on sperm concentration, motility, and male reproductive success were evaluated in adult (P1) Sprague–Dawley rats implanted with 0, 12, or 20, DU pellets of 1 Â 2 mm or 12 or 20 tantalum (Ta) steel pellets of 1 Â 2 mm. Twenty DU pellets of 1 Â 2 mm (760 mg) implanted in a 500-g rat are equal to approximately 0.2 pound of DU in a